Mice
Two-photon imaging
We use two-photon imaging to track the dynamics of genetically encoded fluorescent indicators at a cellular scale. With a chronically implanted cranial window, we can track how neurons and glia adapt their activity during complex behaviors and following acoustic trauma.
Widefield imaging
We document the mesoscale organization of sensory cortex via widefield imaging of intrinsic signals or GCaMP.
Fiber photometry
We express GCaMP or genetically encoded fluorescent sensors to measure neural activity and endogenous neurotransmitter release via implanted optic fibers.
Optogenetics
We transduce neurons with light-activated opsins to “tag” genetically identified cell types and turn their activity levels up and down. Optogenetics helps us establish the causal role of neural activity in perception.
Animal behavioral assessments
We use involuntary behaviors, operant psychophysical behaviors, Pavlovian conditioned paradigms, and naturalistic auditory foraging behaviors to study active listening and auditory learning
Electrophysiology
We use high-density multi-regional extracellular recordings of single unit ensembles to characterize auditory processing and plasticity at a cellular scale with millisecond temporal resolution
Human subjects
EEG
We use 64-channel scalp EEG electrode caps to measure neural synchronization to sound and its modulation by internal state variables and multi-sensory stimulation
Self-Directed Audiometry
We perform a wide range of audiometric and psychoacoustic measurements via mobile devices running custom software and calibrated headphones
Auditory autonomic measurements
We measure skin conductance alongside high-speed videography of facial movements and pupil fluctuations to study affective sound processing.
Auditory training software
We develop novel audiomotor training interfaces using commercial software game engines